Drive east on U.S. Route 60 from Poplar Bluff to Sikeston, Missouri, covering 51 miles of a modernized highway corridor built to near-Interstate standards and forming part of the future I-57 alignment across southeast Missouri.
U.S. Numbered Highway System
Explore the U.S. Numbered Highway System—historic routes, major corridors, and scenic roads connecting every region of the country. Learn more about U.S. Highways across America.
The U.S. Numbered Highway System—often referred to as U.S. Routes or U.S. Highways—is a nationwide network of roads established in 1926 to improve long-distance automobile travel across the United States. Unlike the Interstate system, U.S. Highways predate freeways and often serve as main streets, scenic byways, or vital connectors through rural and urban communities alike. Many historic routes, including iconic roads like U.S. Route 66, trace their roots to this enduring network.
These highways use a grid system for numbering: odd-numbered routes run north–south, increasing from east to west, while even-numbered routes run east–west, increasing from north to south. Important cross-country highways typically end in “0” or “1” (like US 20 or US 1), and three-digit offshoots usually indicate spurs or loops branching from mainline routes.
Today, the U.S. Highway system continues to evolve—some segments have been decommissioned, realigned, or upgraded to freeways—but many routes remain essential for regional travel, trucking, and scenic exploration. This category explores the entire U.S. Numbered Highway network, from coast to coast and border to border.
Discover U.S. Routes
U.S. Route 67: Neelyville to Poplar Bluff ~ Missouri
Drive northbound on U.S. Route 67 from Neelyville to Poplar Bluff, Missouri. This 16-mile segment features a two-lane highway alongside I-57 construction, a four-lane transition at U.S. 160, and a major directional split with U.S. Route 60.
U.S. Route 67: Corning, Arkansas to Missouri
Drive north on U.S. Route 67 from Corning, Arkansas to the Missouri state line. This short Delta corridor transitions from small-town edges to open farmland, offering a calm, uninterrupted look at northeastern Arkansas’s agricultural landscape and regional highway con…
U.S. Route 67: Pocahontas to Corning ~ Arkansas
Experience a 27-mile drive along U.S. Route 67 from Pocahontas to Corning, Arkansas—passing farmland, river woodlands, and small-town landmarks on one of northeast Arkansas’s classic rural corridors.
![U.S. Route 67: Walnut Ridge to Pocahontas [Revisited]](https://mail.openroadarchive.com/wp-content/uploads/2025/12/rrtoxrmakrumaxresdefault.jpg)
U.S. Route 67: Walnut Ridge to Pocahontas [Revisited]
A smooth, 14-mile northbound drive along U.S. Route 67 from Walnut Ridge to Pocahontas, Arkansas, showcasing Delta farmland, emerging Ozark foothills, and key regional junctions including U.S. 412 and U.S. 62.
U.S. Route 278: Corinth, Mississippi to Collierville, Tennessee
Drive 65 miles west on U.S. Route 72 from Corinth, Mississippi to Collierville, Tennessee, passing farmland, rural communities, and the expanding suburbs of the Memphis metro. A smooth four-lane corridor connecting the Tennessee Valley to the edge of the city.
U.S. Route 60: Morganfield to Sturgis ~ Kentucky
Experience a relaxed 10-mile drive along U.S. Route 60 from Morganfield to Sturgis, Kentucky, passing through rolling farmland, rural landscapes, and small-town history in the heart of Union County.
U.S. Route 75: Glenpool to Okmulgee – Oklahoma
Travel 27 miles along U.S. Route 75 from Glenpool to Okmulgee, Oklahoma — a drive that transitions from Tulsa’s suburban edge through farmland and small towns to the historic heart of Okmulgee County.
U.S. Route 64: Russellville to Clarksville – Arkansas
Explore the Arkansas River Valley on U.S. Route 64 from Russellville to Clarksville. This 28-mile drive crosses Lake Dardanelle, passes small towns, and showcases the foothills of the Ozarks.
U.S. Route 70: Sparta to Crossville – Tennessee
Take a scenic drive along U.S. Route 70 from Sparta to Crossville, Tennessee. This 29-mile journey crosses the Cumberland Plateau, passing through wooded ridges, Pleasant Hill, and historic small towns before reaching Crossville.
U.S. Route 64: Pulaski to Fayetteville – Tennessee
Explore U.S. Route 64 from Pulaski to Fayetteville, Tennessee — a 20-mile drive through Giles and Lincoln Counties that blends farmland, rolling hills, and a modern bypass around Fayetteville’s historic core.
U.S. Route 412: Paragould to Walnut Ridge – Arkansas
Travel U.S. Route 412 from Paragould to Walnut Ridge, Arkansas. This 26-mile drive highlights Crowley’s Ridge, Delta farmland, and small-town heritage in northeast Arkansas.