Interstate 65 (I-65) is a major north-south corridor in the central United States, stretching from Mobile, Alabama, to Gary, Indiana. As one of the key arteries of the Interstate Highway System, it serves as a vital link between the Gulf Coast and the Great Lakes region. I-65 passes through four states—Alabama, Tennessee, Kentucky, and Indiana—and connects major cities including Birmingham, Nashville, Louisville, and Indianapolis.
The route is heavily used for both commercial and personal travel, supporting industries from agriculture and manufacturing to logistics. Its alignment closely follows historic north-south travel corridors and is often used as a primary freight route. I-65 intersects with several major east-west interstates, including I-10, I-20, I-40, I-70, and I-80/94, making it a key part of the national transportation grid.
Along its 887-mile stretch, drivers encounter a mix of urban skylines, rolling hills, and rural farmland. Notable features include the scenic Tennessee River crossing, the massive interchange with I-70 in Indianapolis known as the “North Split,” and the towering Mobile River Bridge at its southern end. I-65 continues to play a pivotal role in the movement of people and goods across the central United States.